The Suicidal Ideation Questionnaire (SIQ) and the Suicidal Ideation Questionnaire- Junior (SIQ-Jr) were designed to capture suicidal ideation in adolescents and are often used in clinical trials. Our aim was to identify and appraise the published …
Registry-based randomized controlled trials (RRCTs) have potential to address limitations of traditional clinical trials. To describe their current use, information on planned and published RRCTs was identified and synthesized. A scoping review of …
Pediatric anxiety disorders (AD) are prevalent disorders with an impact on all aspects of a child's life and functioning.1 Although evidence supports commonly used treatments, there are notable concerns with the research to date.2 Heterogeneity in …
Background: Current first-line treatments for paediatric depression demonstrate mild-to-moderate effectiveness. This has spurred a growing body of literature on lifestyle recommendations pertaining to nutrition, sleep and exercise for treating …
Background: Definitions of dichotomous outcome terms, such as “response,” “remission,” and “recovery” are central to the design, interpretation, and clinical application of randomized controlled trials of adolescent depression interventions. …
Background: Many young people with anxiety or depression drop out of treatment early, and/or leave treatment without showing measurably improved symptom levels. To enhance treatment engagement and effectiveness, it is critical to better understand …
Introduction: Over the past decade, the global response to HIV has led to a reduction in the number of new infections, and a decrease in associated mortality. Yet, the number of people living with HIV (PLHIV) is high, with an estimated 38 million …
Major depressive disorder (MDD), associated with a lifetime prevalence rate of 11% in adolescents, results in significant disease burden worldwide. Adolescent MDD clinical trials evaluate interventions by measuring the effects of the interventions on …